Vaccine appointments for a limited number of people aged between 35 and 39-years-old are being made available from Monday.
The Department of Health said it is the latest phase of the vaccine roll out.
It said bookings will open to the entire 35-39 age group by the end of April.
The slots are mainly for the SSE Arena vaccine centre in Belfast and can be booked on a first come first served basis from 14:00 BST.
Appointments in community pharmacies will be made available to 35-39 year olds later this month depending on vaccine supplies.
Patricia Donnelly, who heads up Northern Ireland’s vaccine programme, told the BBC’s Evening Extra programme that vaccine wastage across Northern Ireland is less than 1%.
At the start, the aim was for about 10%. She said across pharmacies it had been a “military operation”.