Israel to expand use of COVID drug that gets 88% of patients out of hospital


The Health Ministry has approved the expanded use of an innovative COVID-19 treatment that helped 15 out of 17 severe patients who took it to be released from the hospital one day after receiving their final dose.

The drug, MesenCure, has been tested by Rambam Medical Center as part of a Phase I/II trial. The ministry has approved allowing any interested Israeli hospital to take part in the Phase II trial and to use the drug for additional approved patients.

The goal of the expanded trial, which will include a minimum of 50 patients, is to confirm the safety and efficacy of the drug, which was developed by Bonus BioGroup.

MesenCure, which consists of activated Mesenchymal Stromal Cells (MSCs) that are isolated from the adipose tissue of healthy donors, was found to reduce inflammation and alleviate respiratory and other symptoms in patients suffering from life-threatening respiratory distress brought on by COVID-19.

Back in May, the company reported on 10 COVID patients between the ages of 45 to 75, all with severe symptoms. Ninety percent of them also had comorbidities.

The data showed a 40% decrease in lung inflammation from treatment – from 55% to 15%, as seen in chest X-rays, in the first five days after treatment. One month later, lung inflammation reached 1%.

Additionally, patients showed significantly improved respiratory function, with blood oxygen saturation increasing to 95% and lung functioning returning to almost entirely normal levels after only one month.