The Oxford-AstraZeneca vaccine has been approved for use in the UK, with the first doses due to be given on Monday amid rising coronavirus cases.
The UK has ordered 100 million doses – enough to vaccinate 50 million people.
This will cover the entire population, when combined with the full order of the Pfizer-BioNTech jab, Health Secretary Matt Hancock said.
It comes as millions more people in England are expected to be placed under the toughest tier four restrictions.
Prime Minister Boris Johnson called the development “a triumph” for British science, adding: “We will now move to vaccinate as many people as quickly as possible.”
And England’s chief medical officer Chris Whitty praised the “considerable collective effort that has brought us to this point”.
Speaking on BBC Breakfast, Mr Hancock said the development was a “significant moment” in the fight against the virus.
It is the second jab to be approved in the UK after the Pfizer-BioNTech vaccine was given the go-ahead in December.
More than 600,000 people in the UK have been vaccinated since Margaret Keenan became the first in the world to be given it outside of a clinical trial.
Unlike the Pfizer-BioNTech jab, which needs ultra cold storage at -70C, the Oxford-AstraZeneca can be stored in a standard fridge so will be easier to deliver to care homes and GP surgeries.
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